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5-fluorouracil in the treatment of scleroderma: a randomised, double blind, placebo controlled international
J A Casas1, P A Saway, I Villarreal
1Department of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.
Annals of the Rheumatic Diseases
|November 1, 1990
Abstract:
A six month controlled study of 5-fluorouracil in the treatment of scleroderma showed a modest benefit in skin scores, Raynaud's phenomenon, and patients' global assessment. Visceral organ and hand function were unaffected. Mild to moderate toxicity was common in the 5-fluorouracil treated patients but usually responded to dose reduction. Two patients receiving 5-fluorouracil died from causes seemingly unrelated to treatment. Significant clinical improvement in scleroderma was not noted in the first six months of treatment with 5-fluorouracil.