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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.

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Related Experiment Video

Updated: May 22, 2026

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

Signaling in cell differentiation and morphogenesis.

M Albert Basson1

  • 1Department of Craniofacial Development, King's College London, United Kingdom. albert.basson@kcl.ac.uk

Cold Spring Harbor Perspectives in Biology
|May 10, 2012
PubMed
Summary
This summary is machine-generated.

During embryonic development, cells interpret genetic code through signaling pathways. Understanding these molecular signals is key to deciphering developmental biology and congenital diseases.

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A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
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Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
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Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay

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Related Experiment Videos

Last Updated: May 22, 2026

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
08:06

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Published on: March 19, 2021

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay
06:49

Analysis of Cell Differentiation, Morphogenesis, and Patterning During Chicken Embryogenesis Using the Soaked-Bead Assay

Published on: January 12, 2022

Area of Science:

  • Developmental Biology
  • Cell Signaling
  • Molecular Biology

Background:

  • The genome of a fertilized oocyte contains all information for organism development.
  • Embryonic development involves complex cellular behaviors driven by signaling molecules.
  • Understanding signal generation, interpretation, and response is crucial in developmental biology.

Purpose of the Study:

  • To review essential signaling pathways in embryonic development.
  • To illustrate mechanisms of signal reception and interpretation by cells.
  • To discuss the regulation of downstream signaling and its impact on cell fate and morphogenesis.

Main Methods:

  • Review of existing scientific literature on developmental signaling pathways.
  • Analysis of mechanisms for cellular signal reception and interpretation.
  • Discussion of regulatory networks in downstream signaling cascades.

Main Results:

  • Signaling pathways are fundamental to translating genetic information into developmental processes.
  • Cells employ specific mechanisms to receive and interpret extracellular signals.
  • Downstream signaling regulates gene expression, affecting cell fate and tissue formation.

Conclusions:

  • Knowledge of signaling pathways significantly enhances understanding of congenital malformations and diseases.
  • Elucidating signal transduction during embryogenesis is central to developmental biology.
  • This review highlights key signaling mechanisms driving embryonic development and cellular responses.