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Updated: May 22, 2026
10:10
Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion
Liyuan Chen1, Qifeng Dang, Chengsheng Liu
1College of Marine Life Sciences, Ocean University of China, Qingdao, 266003, China.
Frontiers of Medicine
|May 11, 2012
Summary
This study enhanced ibuprofen
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Improving drug dissolution and efficacy is crucial for therapeutic success.
- Solid dispersion technology offers a promising approach for enhancing poorly soluble drugs.
Purpose of the Study:
- To enhance the dissolution rate and anti-inflammatory effects of ibuprofen.
- To investigate ibuprofen-urea solid dispersions (SDs) for improved drug delivery.
Main Methods:
- Screening of water-soluble carriers based on ibuprofen solubility.
- Preparation of ibuprofen-urea solid dispersions (SDs).
- Characterization using DSC, XRD, SEM, FTIR, and in vitro dissolution studies.
- Evaluation of anti-inflammatory activity using the mouse ear edema test.
Main Results:
- Urea was identified as a suitable carrier for ibuprofen solid dispersion.
- Solid dispersions significantly improved ibuprofen's in vitro dissolution rate.
- Ibuprofen-urea SDs exhibited enhanced anti-inflammatory effects compared to conventional tablets.
- Characterization confirmed ibuprofen precipitation in crystalline/amorphous forms without drug-carrier interaction.
Conclusions:
- Ibuprofen-urea solid dispersions effectively enhance both dissolution rate and anti-inflammatory activity.
- This approach offers a viable strategy for improving ibuprofen's therapeutic performance.
- Solid dispersion technology holds potential for optimizing the delivery of poorly soluble drugs.
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