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The effect of chlorpheniramine on asthma
A R Ricci1, R J Settipane, B M Goldstein
1Brown University Program in Medicine, Division of Allergy, Rhode Island Hospital, Providence 02903.
Allergy Proceedings : the Official Journal of Regional and State Allergy Societies
|September 1, 1990
Summary
Oral antihistamines like chlorpheniramine are safe for patients with stable or steroid-dependent asthma. These medications do not cause significant harmful effects, making FDA warning labels for asthmatics unnecessary.
Area of Science:
- Pharmacology
- Pulmonology
- Allergy and Immunology
Background:
- Asthma management often involves considering potential medication side effects.
- Antihistamines are commonly used for allergic conditions, raising questions about their safety in asthma patients.
Purpose of the Study:
- To evaluate the safety and tolerability of oral antihistamines in patients with stable asthma.
- To assess the effects of antihistamines in patients with steroid-dependent asthma.
Main Methods:
- The study assessed patients with stable asthma and steroid-dependent asthma.
- Tolerability of oral antihistamines, specifically chlorpheniramine, was evaluated on short- and long-term bases.
Main Results:
- Patients with stable asthma tolerated antihistamines without significant adverse effects.
- Patients with steroid-dependent asthma also showed good tolerance to antihistamines.
- Oral chlorpheniramine demonstrated no ill effects in asthma patients.
Conclusions:
- Oral antihistamines, including chlorpheniramine, are safe for asthma patients.
- Current FDA warning labels regarding antihistamine use in asthmatics are not supported by this evidence.