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Updated: May 22, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Porphyrin dyads linked by a rotatable 3,3'-biphenyl scaffold: a new binding motif for small ditopic molecules
Amy R Mulholland1, Pall Thordarson, Emily J Mensforth
1School of Chemistry, Monash University, Clayton, Victoria 3800, Australia.
Abstract:
Synthetic access to a set of metallo- and free base bis-porphyrins has been provided by a stepwise approach involving sequential peptide and Suzuki couplings. Linking these porphyrins through a 3,3'-biphenyl bridge enables cooperative binding to ditopic ligands such as the bipyridyls. Association constants and binding stoichiometry has been determined by spectroscopic/spectrophotometric means and the differences in the binding affinities of a small series of diaza ligands is discussed in the context of structural fit and microscopic association constants.
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