Related Experiment Video
Updated: May 22, 2026
08:55
Expression, Solubilization, and Purification of Eukaryotic Borate Transporters
Published on: March 7, 2019
[Progress in study on organic anion transporters]
1Dept. of Pharmcology, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|May 16, 2012
Summary
Organic anion transporters (OATs) are crucial for eliminating drugs from the kidneys. This review covers OATs' roles in drug interactions, tissue expression, and gender-specific functions.
Area of Science:
- Biochemistry
- Pharmacology
- Physiology
Context:
- Organic anion transporters (OATs) are vital membrane proteins found in barrier epithelia, including the renal proximal tubule, brain, liver, and placenta.
- They handle endogenous compounds like urate and drug metabolites, as well as numerous pharmaceuticals.
Purpose:
- To review the properties and functions of cloned Organic anion transporter family members.
- To detail tissue-specific expression and physiological roles.
- To explore drug-drug interactions and gender-dependent regulation in OATs.
Summary:
- OATs significantly influence renal drug elimination and pharmacokinetics due to their interaction with diverse drugs and endogenous substances.
- This review synthesizes current understanding of OAT family members, highlighting variations in tissue expression and function.
- Key areas covered include physiological roles, drug interactions, and gender-based regulation in both health and disease.
Impact:
- Provides a comprehensive overview of OATs for researchers and clinicians.
- Enhances understanding of drug disposition and potential drug-drug interactions.
- Informs therapeutic strategies by considering tissue-specific OAT activity and gender differences.
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