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A new auronol from Cudrania cochinchinensis
Chwan-Fwu Lin1, Yi-Ju Chen, Yu-Ling Huang
1Department of Cosmetic Science, Chang Gung University of Science and Technology, Tao-Yuan, 33344, Taiwan.
Journal of Asian Natural Products Research
|May 16, 2012
Summary
A new auronol, cudrauronol, was isolated from Cudrania cochinchinensis roots. Several compounds, including xanthones and flavones, demonstrated significant anti-inflammatory activity in macrophage assays.
Area of Science:
- Natural Product Chemistry
- Pharmacology
Background:
- Cudrania cochinchinensis is a plant source of bioactive compounds.
- Xanthones and flavonoids are classes of natural products with known biological activities.
Purpose of the Study:
- To isolate and identify compounds from Cudrania cochinchinensis roots.
- To evaluate the anti-inflammatory potential of isolated compounds.
Main Methods:
- Isolation and structural elucidation of compounds using chromatographic and spectroscopic techniques.
- Assessment of anti-inflammatory activity via nitric oxide inhibition in lipopolysaccharide-stimulated RAW 264.7 macrophages.
Main Results:
- A new auronol, cudrauronol, and ten known compounds were isolated.
- Compounds 2-5 exhibited potent anti-inflammatory effects, surpassing aminoguanidine.
- Specific IC(50) values were determined for active compounds, highlighting significant nitric oxide inhibition.
Conclusions:
- Cudrania cochinchinensis roots are a rich source of diverse bioactive compounds.
- Several isolated xanthones and flavonoids possess significant anti-inflammatory properties.
- The study identifies potential therapeutic leads for inflammatory conditions.
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