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Related Experiment Video

Updated: May 22, 2026

Guide Wire Assisted Catheterization and Colored Dye Injection for Vascular Mapping of Monochorionic Twin Placentas
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First trimester transabdominal chorionic villus sampling--does the needle matter?

Joseph R Wax1, Angelina Cartin, Renée Chard

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA.

Journal of Clinical Ultrasound : JCU
|May 16, 2012
PubMed
Summary
This summary is machine-generated.

Lancet needles yield larger transabdominal chorionic villus samples (TA-CVS), improving in situ hybridization success and speeding up results compared to amniocentesis needles.

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Area of Science:

  • Perinatal Medicine
  • Fetal Medicine
  • Genetic Testing

Background:

  • First-trimester genetic testing is crucial for prenatal diagnosis.
  • Transabdominal chorionic villus sampling (TA-CVS) is a common invasive procedure.
  • Optimizing TA-CVS technique can improve diagnostic accuracy and efficiency.

Purpose of the Study:

  • To compare the efficacy of 20-gauge amniocentesis needles versus lancet needles for transabdominal chorionic villus sampling (TA-CVS).
  • To evaluate needle type's impact on sample size, genetic analysis success, and turnaround time.

Main Methods:

  • Retrospective study of TA-CVS procedures performed between January 2009 and March 2011.
  • Single operator utilized freehand technique with either amniocentesis needles or lancet needles.
  • All samples processed by a single laboratory for consistent analysis.

Main Results:

  • Lancet needles produced significantly larger samples (median 18 vs. 7 mg).
  • In situ hybridization success rates were higher with lancet needles (96% vs. 74.2%).
  • Lancet needles led to faster result reporting (median 7 vs. 9 days).

Conclusions:

  • Needle selection for 20-gauge TA-CVS can clinically impact procedural outcomes.
  • Lancet needles offer advantages in sample yield, diagnostic efficiency, and speed.
  • This finding is important for optimizing first-trimester invasive prenatal testing.