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Updated: May 22, 2026
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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Comprehensive chromosome screening and embryo selection: moving toward single euploid blastocyst transfer
Eric J Forman1, Kathleen H Hong, Nathan R Treff
1Reproductive Medicine Associates of New Jersey, Morristown, NJ 07960, USA. eforman@rmanj.com
Seminars in Reproductive Medicine
|May 16, 2012
Summary
Comprehensive chromosome screening (CCS) offers renewed potential for embryo selection. This method, with strong evidence of accuracy and efficacy, may enable successful elective single embryo transfer and identify new biomarkers for improved reproductive outcomes.
Area of Science:
- Reproductive Medicine
- Genetics
- Embryology
Background:
- Renewed interest in aneuploidy screening for embryo selection.
- Advancements in comprehensive chromosome screening (CCS) evaluating all 24 chromosomes.
Purpose of the Study:
- To review the critical components of valid CCS embryo selection methodology.
- To discuss limitations and opportunities for routine application in reproductive medicine.
Main Methods:
- Evaluation of CCS accuracy, reliability, safety, predictive value, and clinical efficacy through Level I evidence experiments.
- Incorporation of CCS in research and development to control for chromosomal contribution.
Main Results:
- CCS-based selection of a single euploid blastocyst shows potential for elective single embryo transfer.
- CCS facilitates identification of additional biomarkers to enhance embryo selection efficacy.
Conclusions:
- CCS represents a significant advancement in embryo selection technology.
- Further research and development are needed for routine clinical application of CCS in reproductive medicine.
