Related Experiment Video
Updated: May 22, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
1-(2-Hy-droxy-eth-yl)-3-phenyl-thio-urea
Abstract:
The title compound, C(9)H(12)N(2)OS, was obtained unexpectedly in a multicomponent reaction of an equimolar ratio of phenyl isothio-cyanate, malononitrile and amino-ethanol. The -C(H(2))-N(H)-(C=S)-N(H)- methyl-thio-urea-methane group is almost normal to the phenyl ring, with a dihedral angle of 71.13 (9)°. The N-C-C-O torsion angle is 72.8 (2)°. In the crystal, mol-ecules are connected by N-H⋯O, O-H⋯S and N-H⋯O hydrogen bonds, forming a three-dimensional network.
Related Concept Videos
Antihypertensive Drugs: Thiazide-Class Diuretics
Preparation and Reactions of Sulfides
Diazonium Group Substitution: –OH and –H
Preparation of 1° Amines: Gabriel Synthesis
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview
Preparation and Reactions of Thiols

