Related Experiment Video
Updated: May 22, 2026
08:38
A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model
Published on: March 3, 2023
Interleukin-33 and the function of innate lymphoid cells
Ananda S Mirchandani1, Robert J Salmond, Foo Y Liew
1Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow Biomedical Research Centre, 120 University Place, Glasgow G12 8TA, UK.
Trends in Immunology
|May 22, 2012
Summary
Interleukin-33 (IL-33) regulates immune responses and is involved in type 2 immunity. This cytokine plays dual roles, contributing to both protective immunity and allergic inflammation.
Area of Science:
- Immunology
- Cytokine Biology
- Type 2 Immunity
Background:
- Interleukin-33 (IL-33) is a key cytokine in the IL-1 family.
- IL-33 is crucial for initiating and executing type 2 immune responses.
- It influences both innate and adaptive immunity and is linked to various diseases.
Purpose of the Study:
- To review recent findings on the role of IL-33.
- To highlight the dual functions of IL-33 in immune responses.
- To discuss IL-33's involvement in parasitic infections and allergic airway inflammation.
Main Methods:
- Literature review of recent studies on IL-33.
- Analysis of IL-33's function in innate and adaptive immunity.
- Examination of IL-33's role in specific disease models.
Main Results:
- IL-33 is integral to type 2 immunity.
- It modulates novel innate lymphocyte populations.
- IL-33 exhibits distinct roles in protective and detrimental immune contexts.
Conclusions:
- IL-33 has a significant, multifaceted role in immune regulation.
- Its involvement spans protective responses and pathological conditions like allergies.
- Further research into IL-33's mechanisms is warranted.
Related Concept Videos
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:28Cells of the Innate Immune Response
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:28Functions of the Lymphatic and Immune System
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
01:23Introduction to Lymphatic and Immune System
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...