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Related Concept Videos

Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

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Related Experiment Video

Updated: May 22, 2026

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
05:03

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes

Published on: February 24, 2023

Calcium and bone.

Kun Zhu1, Richard L Prince

  • 1Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, WA, Australia. kun.zhu@uwa.edu.au

Clinical Biochemistry
|May 22, 2012
PubMed
Summary
This summary is machine-generated.

Adequate calcium intake is crucial for building strong bones during childhood and preventing bone loss and fractures in older age. Ensuring sufficient calcium supports peak bone mass and reduces osteoporosis risk throughout life.

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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
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Last Updated: May 22, 2026

A Fluorescent Intravital Imaging Approach to Study Load-Induced Calcium Signaling Dynamics in Mouse Osteocytes
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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Area of Science:

  • Nutritional Science
  • Bone Biology
  • Gerontology

Background:

  • Calcium is an essential mineral vital for skeletal integrity.
  • Bone health is influenced by calcium dynamics from childhood through senescence.
  • Low calcium intake is a global health concern affecting all age groups.

Purpose of the Study:

  • To evaluate the critical role of calcium in maintaining bone health across the lifespan.
  • To determine calcium's impact on bone development and age-related bone loss.

Main Methods:

  • A comprehensive literature review was conducted.
  • The review focused on studies examining calcium's role in bone development during childhood.
  • Adult and elderly bone health in relation to calcium intake was also assessed.

Main Results:

  • Calcium intake significantly influences skeletal calcium retention and peak bone mass attainment.
  • Optimal calcium intake enhances bone mineral accretion, with specific daily recommendations for adolescents.
  • Supplementation in older adults reduces bone loss by up to 1.2% and fracture risk by at least 10%.

Conclusions:

  • Lifelong adequate calcium consumption is essential for optimal bone health.
  • Sufficient calcium intake throughout life is key to preventing osteoporosis and associated fractures.