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The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
Published on: August 11, 2008
Risk factors of multidrug resistant tuberculosis in central Nepal: a pilot study
S B Marahatta1, J Kaewkungwal, P Ramasoota
1Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Thailand.
Kathmandu University Medical Journal (KUMJ)
|May 22, 2012
Summary
Multi-drug resistant tuberculosis (MDR-TB) in Nepal is linked to prior TB history, smoking, social stigma, and poor knowledge of MDR-TB and DOTS Plus. Addressing these factors is crucial for controlling drug-resistant tuberculosis.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- Tuberculosis (TB) is a major infectious disease in Nepal, with rising rates of drug-resistant TB posing a significant public health challenge.
- Drug-resistant tuberculosis threatens the effectiveness of current TB control strategies in the region.
Purpose of the Study:
- To investigate the risk factors associated with multi-drug resistant tuberculosis (MDR-TB) among patients at the National Tuberculosis Centre in Bhaktpur, Nepal.
- To identify key factors contributing to the development of MDR-TB in the Nepalese population.
Main Methods:
- A case-control study was conducted with 55 MDR-TB cases and 55 controls.
- Data was collected over six months (May-October 2010) and analyzed using SPSS, employing chi-square tests and calculating odds ratios (OR) with 95% confidence intervals (CI).
Main Results:
- Significant risk factors for MDR-TB included a history of prior TB (OR = 2.799), smoking habit (OR = 2.350), social stigma (OR = 2.655), and limited knowledge of MDR-TB (OR = 9.643) and DOTS Plus (OR = 16.714).
- No significant association was found between MDR-TB and alcohol consumption or room ventilation.
Conclusions:
- Prior TB infection, smoking, social stigma, and inadequate knowledge regarding MDR-TB and its treatment (DOTS Plus) are significantly associated with multi-drug resistant tuberculosis in Nepal.
- Interventions should focus on patient education, smoking cessation, and mitigating social stigma to improve MDR-TB control efforts.
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