Related Experiment Video
Updated: May 22, 2026
04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Triiodothyronin, thyroxine and thyrotropin in vitiligo
1Department of Paediatrics, B&B Hospital, Gwarko, Lalitpur, Nepal. phuche_001@yahoo.com
Kathmandu University Medical Journal (KUMJ)
|May 22, 2012
Summary
Vitiligo patients frequently exhibit abnormal thyroid function tests, with nearly 40% showing irregularities in T3, T4, or TSH levels. Early thyroid screening is crucial for vitiligo patients to prevent complications.
Area of Science:
- Dermatology
- Endocrinology
- Immunology
Background:
- Vitiligo is a common global skin pigment disorder.
- It is psychologically distressing and often linked to autoimmune conditions.
- Immune system dysfunction may underlie vitiligo manifestations.
Purpose of the Study:
- To investigate the prevalence and types of abnormal thyroid function tests in vitiligo patients.
- To establish the association between vitiligo and thyroid disorders.
Main Methods:
- A prospective cross-sectional study was conducted.
- Thyroid function tests (TFTs) were assessed in 66 vitiligo patients.
- Data collected from November 2008 to January 2011 at Dhulikhel Hospital.
Main Results:
- Nearly 40% (26 out of 66) of vitiligo patients had abnormal TFTs.
- Abnormalities included elevated or decreased T3, T4, and TSH levels.
- Specific findings included 10 abnormal T3, 7 abnormal T4, and 12 abnormal TSH results.
Conclusions:
- A significant association exists between vitiligo and thyroid disorders.
- Vitiligo patients should undergo routine thyroid function testing.
- Early detection and management of thyroid disorders can prevent long-term complications.
Related Concept Videos
01:20Synthesis and Regulation of Thyroid Hormones
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
01:23Hypothyroidism II: Pathophysiology
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:18Functions of Thyroid Hormones
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:25Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...