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Ipilimumab-induced colitis on FDG PET/CT
Ashima Lyall1, Herbert Alberto Vargas, Richard D Carvajal
1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Ipilimumab treatment for melanoma can cause colitis, an immune-related side effect. FDG PET/CT imaging can help detect this toxicity, which often resolves with steroid treatment.
Area of Science:
- Oncology
- Immunology
- Radiology
Background:
- Metastatic melanoma treatment often involves immunotherapy, such as ipilimumab.
- Ipilimumab can induce immune-mediated toxicities, with enterocolitis being a common adverse event.
Observation:
- A patient receiving ipilimumab for metastatic melanoma developed symptoms of enterocolitis, including diarrhea, sweats, and chills.
- FDG PET/CT revealed diffuse, FDG-avid colonic wall thickening, characteristic of inflammation.
Findings:
- The imaging findings were consistent with ipilimumab-induced colitis.
- The patient's symptoms resolved after treatment with systemic steroids, confirming the diagnosis of immune-mediated enterocolitis.
Implications:
- Physicians should consider ipilimumab-induced enterocolitis in patients on this immunotherapy presenting with gastrointestinal symptoms.
- FDG PET/CT can be a valuable tool in diagnosing immune-mediated toxicities associated with ipilimumab therapy.
- Awareness of these potential toxicities is crucial for accurate interpretation of imaging studies in patients undergoing ipilimumab treatment.
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