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Ipilimumab-induced colitis on FDG PET/CT

Ashima Lyall1, Herbert Alberto Vargas, Richard D Carvajal

  • 1Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Clinical Nuclear Medicine
|May 23, 2012
PubMed

A 52-year-old woman with metastatic melanoma was treated with ipilimumab. After 2 cycles of treatment, she developed watery diarrhea, sweats, and chills. An FDG PET/CT study demonstrated new FDG-avid (maximum standardized uptake value 15.6) diffuse colonic wall thickening, suggestive of ipilimumab-induced colitis. The patient was treated with systemic steroids, with subsequent resolution of her symptoms. Based on the response to steroids, the diagnosis of ipilimumab-induced enterocolitis was made. Ipilimumab may cause several immune-mediated toxicities, the most common of which is enterocolitis. Physicians interpreting FDG PET/CT examinations of patients treated with ipilimumab should be aware of these FDG-avid immune-mediated toxicities.

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