Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

New pharmacological studies with pentoxifylline.

W J Novick1, G Sullivan, G Mandell

  • 1Hoechst-Roussel Pharmaceuticals Inc., Somerville, NJ.

Biorheology
|January 1, 1990
PubMed
Summary

Pentoxifylline effectively blocks tumor necrosis factor alpha (TNF α) activation of polymorphonuclear cells (PMNs) and reduces amphotericin B activation. This suggests pentoxifylline may mitigate PMN overactivation and related toxic effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "RIFM fragrance ingredient safety assessment, cinnamaldehyde, CAS Registry Number 104-55-2" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110710].

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2020
Same author

Corrigendum to RIFM fragrance ingredient safety assessment, cinnamaldehyde, CAS Registry Number 104-55-2 [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110710].

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2020
Same author

Corrigendum to "RIFM fragrance ingredient safety assessment, methoxy dicyclopentadiene carboxaldehyde, CAS Registry Number 86803-90-9" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110826].

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2020
Same author

Corrigendum to "RIFM fragrance ingredient safety assessment, 3,3-dimethyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)-4-penten-2-ol, CAS Registry Number 107898-54-4" [Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110715].

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2020
Same author

Corrigendum to "RIFM fragrance ingredient safety assessment, 4-(isopropyl)-β-methylcyclohexanethanol, CAS Registry Number 67634-03-1"[Food Chem. Toxicol. 134 (Suppl. 1) (2019) 110713].

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2020
Same author

Corrigendum to "RIFM fragrance ingredient safety assessment, β,β,3-trimethyl benzenepropanol", CAS registry number 103694-68-4 [Food Chem. Toxicol. 130 Suppl. 1 (2019) 110650].

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2020

Area of Science:

  • Immunology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Polymorphonuclear (PMN) overactivation contributes to microcirculation issues and multiorgan failure (MOF).
  • Pentoxifylline is known to inhibit PMN activation by endotoxins and cytokines like TNF α and IL-1.
  • Pentoxifylline has demonstrated protective effects against IL-2-induced MOF in animal models.

Purpose of the Study:

  • To investigate the temporal relationship between pentoxifylline administration and TNF α-induced PMN activation.
  • To assess the effects of pentoxifylline on PMN activation induced by amphotericin B.

Main Methods:

  • Evaluating the timing of pentoxifylline's inhibitory effect on TNF α-mediated PMN activation.
  • Assessing PMN activation markers (chemotaxis, chemiluminescence, spreading) following amphotericin B exposure with and without pentoxifylline.

Main Results:

  • Pentoxifylline effectively blocked TNF α activation of PMNs, regardless of whether it was administered before or after TNF α.
  • Pentoxifylline reduced PMN activation by amphotericin B, as evidenced by decreased chemotaxis and spreading, and altered chemiluminescence.

Conclusions:

  • Pentoxifylline demonstrates the ability to reverse TNF α-induced PMN activation.
  • Pentoxifylline may possess therapeutic potential in mitigating the toxic effects associated with amphotericin B-induced PMN activation.

Related Experiment Videos