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Updated: May 22, 2026

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Transmission Raman spectroscopy for quality control in model cocrystal tablets
Jonathan C Burley1, Aalae Alkhalil, Matthew Bloomfield
1School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK. jonathan.burley@nottingham.ac.uk
Transmission Raman spectroscopy successfully analyzed tabletted cocrystals for the first time. This method distinguishes formulations by drug loading and chemical composition, differentiating cocrystals from their separate components.
Area of Science:
- Pharmaceutical sciences
- Analytical chemistry
- Solid-state chemistry
Background:
- Cocrystals are advanced pharmaceutical formulations improving drug properties.
- Characterizing cocrystal formulations is crucial for quality control.
- Existing analytical methods may have limitations in differentiating complex formulations.
Purpose of the Study:
- To evaluate transmission Raman spectroscopy for analyzing tabletted cocrystal formulations.
- To determine if transmission Raman can differentiate formulations based on drug loading.
- To assess the technique's capability in distinguishing cocrystal chemistry from individual components.
Main Methods:
- Utilizing transmission Raman spectroscopy.
- Analyzing model formulations containing tabletted cocrystals.
- Comparing spectral data to assess formulation differences.
Main Results:
- Transmission Raman spectroscopy effectively differentiated between formulations.
- The technique distinguished formulations based on varying drug loading.
- Spectral analysis successfully identified the chemical differences between cocrystals and their separate components.
Conclusions:
- Transmission Raman spectroscopy is a viable technique for analyzing tabletted cocrystal formulations.
- The method offers a non-destructive way to assess drug loading and chemical identity in cocrystals.
- This spectroscopic approach provides valuable insights into pharmaceutical formulation characterization.
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