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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

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Related Experiment Videos

Nested PCR-positive tubercular ampiginous choroiditis: a case report.

Sagar Sudhakar Bhuibhar, Jyotirmay Biswas

    Ocular Immunology and Inflammation
    |May 25, 2012
    PubMed
    Summary

    Tuberculosis can cause ampiginous choroiditis, a severe eye condition. Nested PCR (polymerase chain reaction) on aqueous samples confirms tuberculosis (TB) as the cause, aiding diagnosis and treatment.

    Area of Science:

    • Ophthalmology
    • Infectious Diseases
    • Molecular Diagnostics

    Background:

    • Ocular tuberculosis is a significant cause of chronic or recurrent choroiditis, particularly in TB-endemic regions.
    • Accurate etiological diagnosis is crucial for effective management of ocular inflammatory conditions.

    Observation:

    • A case of ampiginous choroiditis with no systemic TB signs, but positive QuantiFERON TB gold test and lymphadenopathy, is presented.
    • Initial treatment with anti-tubercular drugs and steroids showed inadequate response.

    Findings:

    • Nested PCR (nPCR) on aqueous humor confirmed Mycobacterium tuberculosis (M.tb) presence by detecting the MPB64 gene.
    • Continued anti-TB treatment led to regression of choroiditis, despite initial poor response.

    Related Experiment Videos

    Implications:

    • Nested PCR on intraocular fluid is a highly sensitive and specific tool for confirming tubercular etiology in suspected ocular TB.
    • This diagnostic approach aids in consolidating the etiological diagnosis and guiding appropriate treatment for challenging cases of choroiditis.