Related Experiment Video
Updated: May 22, 2026
12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Tertiary lymphoid organs in infection and autoimmunity
Katrijn Neyt1, Frédéric Perros, Corine H GeurtsvanKessel
1Laboratory of Immunoregulation and Mucosal Immunology, Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
Trends in Immunology
|May 25, 2012
Summary
Tertiary lymphoid organs (TLOs) mimic lymph node structures, forming during chronic immune responses. This review explores TLO formation, induction triggers, and their roles in immunity, transplantation, and autoimmune diseases.
Area of Science:
- Immunology
- Cell Biology
- Pathology
Background:
- Lymph nodes (LNs) and spleen possess specialized structures facilitating immune cell interactions.
- Tertiary lymphoid organs (TLOs) are organized immune structures that can arise at sites of inflammation.
Purpose of the Study:
- To review the molecular mechanisms underlying TLO formation and maintenance.
- To discuss the controversies regarding events that induce TLO formation.
- To examine the functional significance of TLOs in various pathological conditions.
Main Methods:
- Literature review of studies on TLOs.
- Analysis of molecular mechanisms involved in TLO development.
- Synthesis of data on TLO functions in different disease models.
Main Results:
- TLOs share structural and cellular similarities with secondary lymphoid organs.
- TLO formation is associated with chronic immune stimulation and infection.
- Specific molecular pathways govern TLO development and organization.
Conclusions:
- TLOs are dynamic structures with significant roles in adaptive immunity.
- Understanding TLOs offers insights into managing infections, transplantation outcomes, and autoimmune diseases.
More Related Videos
Related Concept Videos
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:28Functions of the Lymphatic and Immune System
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
01:23Cells of the Adaptive Immune Response
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
01:23Introduction to Lymphatic and Immune System
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...