Related Experiment Video
Updated: May 22, 2026
07:07
Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
Published on: February 21, 2016
Planar cell polarity genes, Celsr1-3, in neural development
Jia Feng1, Qi Han, Libing Zhou
1Joint Laboratory for Brain Function and Health, Jinan University and The University of Hong Kong, Medical School of Jinan University, Guangzhou 510632, China.
Neuroscience Bulletin
|May 25, 2012
Summary
Flamingo proteins are crucial for cell polarity and neuronal development in flies and mammals. Mammalian Celsr1-3 genes cooperate in neural development, impacting axon guidance and cell migration.
Area of Science:
- Cell Biology
- Developmental Biology
- Neuroscience
Background:
- Flamingo proteins belong to a unique cadherin subfamily with distinct structural features compared to classic cadherins.
- Drosophila Flamingo plays key roles in epithelial polarity and neuronal morphogenesis.
- Mammalian orthologs (Celsr1-3) are expressed in the nervous system and are implicated in neural development.
Purpose of the Study:
- To investigate the roles and interactions of mammalian Flamingo orthologs (Celsr1-3) in neural development.
Main Methods:
- Comparative analysis of Flamingo/Celsr protein structure.
- Examination of Celsr1-3 gene knockout mouse phenotypes.
- Assessment of Celsr1-3 cooperative interactions in neural development.
Main Results:
- Mammalian Celsr1-3 proteins are involved in critical neural processes including axon guidance, neuronal migration, and cilium polarity.
- Single-gene knockout mice for Celsr1-3 display varied phenotypes.
- Evidence suggests cooperative interactions among Celsr1-3 genes.
Conclusions:
- Mammalian Celsr proteins are essential for multiple aspects of neural development.
- Cooperative functions among Celsr1-3 genes are important for normal neural development.
More Related Videos
Related Concept Videos
01:21Cell Polarization by Rho Proteins
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
01:51Determination
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
01:30Neurulation
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
02:13Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
01:41Non-Canonical Wnt Signaling Pathways
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
01:22Microtubules in Signaling
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...