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Published on: July 18, 2016
Carisoprodol concentrations from different anatomical sites: three overdose cases
R C Backer1, R Zumwalt, P McFeeley
1Office of the Medical Investigator, State of New Mexico, Albuquerque.
Journal of Analytical Toxicology
|September 1, 1990
Summary
This study details three carisoprodol overdose cases. Carisoprodol and meprobamate levels were measured in biological samples using gas chromatography/mass spectrometry for forensic analysis.
Area of Science:
- Forensic Toxicology
- Pharmacology
Background:
- Carisoprodol is a muscle relaxant with potential for abuse and overdose.
- Understanding carisoprodol and its metabolite pharmacokinetics is crucial for clinical and forensic toxicology.
Observation:
- Three cases of carisoprodol overdose were documented.
- Biological samples (urine, blood, vitreous humor, heart) were collected from the cases.
- Carisoprodol and its primary metabolite, meprobamate, were the focus of analysis.
Findings:
- Gas chromatography/mass spectrometry (GC/MS) was employed for precise drug quantification.
- Concentrations of carisoprodol and meprobamate were determined across various biological matrices.
- The data provides quantitative insights into carisoprodol distribution and metabolism in overdose scenarios.
Implications:
- This case series contributes valuable quantitative data for interpreting carisoprodol and meprobamate levels in forensic investigations.
- The findings can aid in diagnosing and managing carisoprodol toxicity.
- GC/MS provides a reliable method for detecting and quantifying these substances in post-mortem and clinical toxicology.
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