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Published on: December 15, 2010
Endoscopic ultrasound-guided antitumor agents
Yousuke Nakai1, Kenneth J Chang
1Division of Gastroenterology and Hepatology, H.H. Chao Comprehensive Digestive Disease Center, University of California, Irvine, 101 The City Drive, Orange, CA 92868, USA.
Gastrointestinal Endoscopy Clinics of North America
|May 29, 2012
Summary
Endoscopic ultrasonography (EUS) is now an interventional tool thanks to real-time needle guidance. EUS-guided fine-needle injection (EUS-FNI) shows promise for minimally invasive cancer therapies.
Area of Science:
- Gastroenterology
- Interventional Endoscopy
- Oncology
Background:
- Endoscopic ultrasonography (EUS) has evolved from a diagnostic to an interventional tool.
- Real-time guidance of needle advancement is a key technological development.
- Minimally invasive delivery systems are crucial for targeted cancer therapies.
Purpose of the Study:
- To highlight the transformation of EUS into an interventional procedure.
- To introduce EUS-guided fine-needle injection (EUS-FNI) as a novel therapeutic delivery system.
- To review the feasibility and potential of EUS-FNI for esophageal and pancreatic cancers.
Main Methods:
- Utilizing linear-array endoscopic ultrasonography for real-time guidance.
- Employing fine-needle injection techniques for targeted delivery of agents.
- Focusing on applications in local (intratumoral) and combination therapies.
Main Results:
- EUS-FNI has demonstrated feasibility as a minimally invasive delivery system.
- Promising results are emerging for the treatment of esophageal and pancreatic cancers.
- Evidence supporting EUS-FNI for antitumor agent delivery is expanding.
Conclusions:
- EUS-guided fine-needle injection represents a significant advancement in interventional endoscopy.
- EUS-FNI offers a promising minimally invasive approach for localized cancer treatment.
- Further research is warranted to fully explore the therapeutic potential of EUS-FNI in oncology.
