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Published on: August 23, 2018
Alpinetin/hydroxypropyl-β-cyclodextrin host-guest system: preparation, characterization, inclusion mode,
Shui-Xian Ma1, Wen Chen, Xiao-Dong Yang
1Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650500, PR China.
Alpinetin
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Alpinetin is a natural flavonoid with potential therapeutic properties.
- Improving the water solubility and stability of alpinetin is crucial for its pharmaceutical applications.
Purpose of the Study:
- To investigate the inclusion complexation of alpinetin with hydroxypropyl-β-cyclodextrin (HPβCD).
- To characterize the complex and evaluate its binding ability.
Main Methods:
- UV-vis spectroscopy
- FT-IR spectroscopy
- Nuclear Magnetic Resonance (¹H and 2D NMR)
- X-ray Diffraction (XRD)
- Scanning Electron Microscopy (SEM)
- Differential Scanning Calorimetry (DSC)
Main Results:
- Alpinetin formed an inclusion complex with HPβCD.
- The water solubility and stability of alpinetin were significantly enhanced within the complex.
- Characterization confirmed complex formation in both solution and solid states.
Conclusions:
- The alpinetin/HPβCD inclusion complex demonstrates improved physicochemical properties.
- This complex holds potential for development into herbal medicines and healthcare products.
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