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Cyclic Vomiting Syndrome (CVS): is there a difference based on onset of symptoms--pediatric versus adult?

Nilay Kumar1, Qumseya Bashar, Naveen Reddy

  • 1Department of Gastroenterology and Hepatology, Medical College of Wisconsin, 4th Floor, Froedtert East Building, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA.

BMC Gastroenterology
|May 30, 2012
PubMed

Insights

Cyclic Vomiting Syndrome (CVS) in adults and children share similar clinical features and treatment responses, with most patients benefiting from standard therapies. Patient compliance is key to successful treatment outcomes for this functional gastrointestinal disorder.

Area of Science:

  • Gastroenterology
  • Pediatrics
  • Genetics

Background:

  • Cyclic Vomiting Syndrome (CVS) is recognized in children but poorly understood in adults.
  • Recent studies suggest genetic differences between pediatric- and adult-onset CVS.
  • Clinical features and treatment response differences remain understudied.

Purpose of the Study:

  • To compare clinical features and treatment responses in pediatric-onset versus adult-onset CVS.
  • To identify factors influencing treatment outcomes in CVS patients.

Main Methods:

  • Retrospective review of 101 CVS patients diagnosed using Rome III criteria.
  • Comparison of clinical characteristics and treatment outcomes between pediatric-onset (<18 years) and adult-onset CVS groups.

Main Results:

  • Pediatric-onset CVS patients were more likely to be female and had a higher prevalence of CVS plus.
  • Longer diagnostic delays were observed in the pediatric-onset group.
  • Most patients (86%) responded to standard therapies (tricyclic antidepressants, anticonvulsants, CoQ10, L-carnitine).
  • Patient compliance was the only significant factor associated with treatment response on multivariate analysis.

Conclusions:

  • Clinical features and response to standard therapy are largely similar between pediatric- and adult-onset CVS.
  • Most CVS patients respond well to treatment.
  • Patient compliance is crucial for successful CVS management.
Abstract

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