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Related Experiment Video

Updated: May 22, 2026

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods

Identification of Orexin and Endocannabinoid Receptors in Adult Zebrafish Using Immunoperoxidase and Immunofluorescence Methods

Published on: June 25, 2019

Orexin system in teleost fish.

Kouhei Matsuda¹, Morio Azuma, Ki Sung Kang

¹Laboratory of Regulatory Biology, Graduate School of Science and Engineering, University of Toyama, Toyama, Japan.

Vitamins and Hormones

|May 30, 2012

Summary

Orexin neuropeptides regulate feeding and activity in fish, similar to mammals. Studies in goldfish and zebrafish reveal orexin

Area of Science:

Neuroscience
Comparative Physiology
Endocrinology

Background:

Orexin is a conserved neuropeptide system found across vertebrates.
In mammals, orexin regulates feeding, locomotion, and sleep-wake cycles.
Recent research indicates orexin influences behavior in nonmammalian vertebrates, including fish.

Purpose of the Study:

To review current knowledge of the orexin system in teleost fish.
To focus on the behavioral roles of orexin in fish models.
To examine the comparative significance of orexin from a cross-species perspective.

Main Methods:

Literature review of studies on orexin in teleost fish (goldfish, zebrafish).
Analysis of research identifying and characterizing orexin and its receptor.

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Examination of functional studies demonstrating orexin's behavioral effects.

Main Results:

Orexin acts as an orexigenic factor, increasing food consumption in teleost fish.
Orexin enhances locomotor activity in fish models.
The orexin system in fish regulates active/rest states, including circadian rhythms and sleep/wakefulness.

Conclusions:

The orexin system plays conserved roles in regulating feeding and activity across vertebrate species.
Teleost fish serve as valuable models for understanding orexin's fundamental functions.
Comparative studies highlight the evolutionary significance of the orexin system in behavior regulation.