Related Experiment Video
Updated: May 21, 2026
03:08
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
Published on: October 3, 2025
A Bioinformatics Resource for TWEAK-Fn14 Signaling Pathway.
Mitali Bhattacharjee1, Rajesh Raju, Aneesha Radhakrishnan
1Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.
Journal of Signal Transduction
|June 1, 2012
Summary
This study details the TWEAK-Fn14 signaling pathway, identifying 46 proteins and 28 gene expressions. This curated pathway may reveal new therapeutic targets for TWEAK-associated disorders.
Area of Science:
- Cellular signaling pathways
- Molecular biology
- Immunology
Background:
- TNF-related weak inducer of apoptosis (TWEAK) is a TNF superfamily member signaling via Fn14 (TNFRSF12A).
- TWEAK-Fn14 interactions regulate critical cellular functions like proliferation, inflammation, and apoptosis.
- While TWEAK is linked to diseases, its downstream signaling events are not well-documented.
Purpose of the Study:
- To manually compile and characterize the downstream molecular events of TWEAK-Fn14 signaling from existing literature.
- To create a comprehensive resource for TWEAK-Fn14 pathway interactions, particularly in human systems.
- To make this pathway data available in standard exchange formats via the NetPath repository.
Main Methods:
- Manual curation of scientific literature focusing on TWEAK-Fn14 signaling.
- Identification and cataloging of proteins and gene expressions involved in the pathway.
- Data organization and deposition into the NetPath signaling pathway repository.
Main Results:
- A detailed TWEAK-Fn14 signaling pathway was constructed, involving 46 proteins.
- The pathway encompasses 28 TWEAK-Fn14 induced gene expressions.
- Pathway data is now accessible through NetPath in standard exchange formats.
Conclusions:
- The compiled TWEAK-Fn14 pathway provides a valuable resource for understanding TWEAK signaling.
- This pathway map can facilitate the discovery of novel signaling components.
- Identification of new components may lead to potential therapeutic targets for TWEAK-related diseases.
Related Concept Videos
02:26NF-κB-dependent Signaling Pathway
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
01:20The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:19Interactions Between Signaling Pathways
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
01:41Non-Canonical Wnt Signaling Pathways
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...