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Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic sinusitis...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Related Experiment Video

Updated: May 21, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Cystic fibrosis.

Nedeljko Radlović1

  • 1School of Medicine, University of Belgrade, Belgrade, Serbia. n.radlovic@beotel.net

Srpski Arhiv Za Celokupno Lekarstvo
|June 2, 2012
PubMed
Summary

Cystic fibrosis (CF) is a genetic disorder affecting multiple organs due to CFTR protein defects. Early diagnosis and multidisciplinary care improve patient survival and quality of life.

Area of Science:

  • Genetics
  • Medical Science
  • Pathology

Background:

  • Cystic fibrosis (CF) is an autosomal recessive disease caused by CFTR protein dysfunction.
  • CFTR protein is a chloride channel crucial for epithelial cells in various glands.
  • The disease primarily affects Caucasian populations, with rarity in other races.

Purpose of the Study:

  • To provide a comprehensive overview of cystic fibrosis.
  • To highlight the genetic basis and clinical manifestations of CF.
  • To discuss diagnostic methods and therapeutic approaches for CF.

Main Methods:

  • Review of existing literature on cystic fibrosis.
  • Analysis of CFTR protein function and its role in disease pathology.
  • Description of diagnostic criteria including sweat chloride levels, blood tests, and genetic mutation verification.

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Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression
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Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression

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Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
08:00

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

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Last Updated: May 21, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression
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Cystic Fibrosis Aggregate Biofilm Model to Study Infection-relevant Gene Expression

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Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study
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Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

Main Results:

  • CFTR protein abnormalities lead to mucosal hyperconcentration and electrolyte imbalances.
  • Clinical features include respiratory, digestive, and reproductive disorders, and dehydration.
  • Exogenous factors like infections and pollution significantly influence disease severity.

Conclusions:

  • CF is a severe, complex chronic disease requiring a multidisciplinary approach.
  • Improved healthcare has led to increased survival and quality of life for CF patients into adulthood.
  • Early diagnosis and comprehensive management are key to better outcomes.