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Updated: May 21, 2026
09:11
Y-90 Radioembolization and PD-1 Inhibitor as Neoadjuvant Treatment in Hepatocellular Carcinoma
Published on: May 24, 2024
Hepatic radioembolization complicated by gastrointestinal ulceration
1Section of Interventional Radiology, Department of Radiology, Northwestern University, Chicago, Illinois.
Seminars in Interventional Radiology
|June 2, 2012
Summary
Gastric ulceration is a rare complication of yttrium 90 (Y90) radioembolization for liver tumors. Improved techniques have reduced its incidence, minimizing risks like bleeding and perforation.
Area of Science:
- Interventional Radiology
- Oncology
- Gastroenterology
Background:
- Gastric ulceration is an uncommon complication of yttrium 90 (Y90) radioembolization therapy for hepatic tumors.
- This complication can lead to serious issues including gastrointestinal bleeding, obstruction, and perforation.
Purpose of the Study:
- To describe the risks and management of gastric ulceration following Y90 radioembolization.
- To highlight methods for reducing the incidence of this complication.
Main Methods:
- Review of vascular anatomy and hepatic arterial flow.
- Assessment of Y90 particulate embolic effect.
- Implementation of coil embolization for at-risk vessels.
Main Results:
- Meticulous attention to vascular details and Y90 properties are crucial for preventing nontarget embolization.
- Advanced techniques have successfully reduced the incidence of radioembolization-associated gastrointestinal ulceration.
Conclusions:
- Yttrium 90 radioembolization requires careful planning to avoid gastrointestinal complications.
- Modern interventional techniques have improved the safety profile of Y90 therapy for liver cancer.
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