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Related Experiment Video

Updated: May 21, 2026

Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
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Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets

Published on: February 22, 2016

Tunable spatial heterogeneity in structure and composition within aqueous microfluidic droplets.

Su Hui Sophia Lee, Pengzhi Wang, Swee Kun Yap

    Biomicrofluidics
    |June 2, 2012
    PubMed
    Summary
    This summary is machine-generated.

    Researchers created tunable microfluidic droplets with complex internal structures using polymer mixtures. This method allows for novel biomolecular applications and biochemical experiments in biomimetic environments.

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    Last Updated: May 21, 2026

    Capillary-based Centrifugal Microfluidic Device for Size-controllable Formation of Monodisperse Microdroplets
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    Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique

    Published on: June 12, 2015

    Area of Science:

    • Fluid Dynamics
    • Materials Science
    • Biotechnology

    Background:

    • Aqueous two-phase systems are increasingly used in microfluidic devices for biomolecular applications.
    • Controlling internal droplet structures is crucial for advanced microfluidic applications.

    Purpose of the Study:

    • To demonstrate biphasic microfluidic droplets with tunable internal structures.
    • To explore non-equilibrium steady-state structures beyond simple drop-in-drop morphologies.
    • To enable new possibilities for biochemical experimentation.

    Main Methods:

    • Utilizing a microfluidic T-junction device with an immiscible oil.
    • Dispensing an aqueous mixture of poly(ethylene glycol) (PEG) and dextran.
    • Investigating droplet behavior above a specific speed threshold.

    Main Results:

    • Achieved broadly tunable internal droplet structures, from equilibrium to non-equilibrium states.
    • Observed stirring of the inner dextran-rich phase within the outer PEG-rich phase.
    • Demonstrated a continuum of speed and composition-dependent phase morphologies.

    Conclusions:

    • Developed a method to generate microfluidic multiple emulsions with complex internal structures.
    • Opened possibilities for biochemical experiments in biomimetic milieus.
    • Advanced the control over internal structures in biphasic microfluidic systems.