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Biguanide-induced lactic acidosis.

H B Chandalia¹, M Rangnath

¹Grant Medical College, Bombay.

The Journal of the Association of Physicians of India

|September 1, 1990

Summary

Phenformin treatment significantly increased blood lactate levels in Indian diabetics, challenging previous assumptions. Prolonged use may lead to adaptation, as indicated by lower lactate levels in long-term users.

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Area of Science:

Endocrinology
Metabolic Disorders
Pharmacology

Background:

Phenformin-induced lactic acidosis was considered rare in India.
Factors like high carbohydrate intake and lower alcoholism rates were thought to reduce risk.