Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Electrochemistry: Overview01:04

Electrochemistry: Overview

Electrochemistry is the branch of chemistry that studies the relationship between electrical quantities and chemical reactions, particularly oxidation and reduction. Oxidation is the loss of electrons from a substance, whereas reduction refers to the gain of electrons. A substance with a strong electron affinity is called an oxidizing agent (oxidant), and a reducing agent (reductant) is a species that donates electrons. Oxidation and reduction processes are pivotal to electrochemical reactions,...
Electrochemical Cells01:28

Electrochemical Cells

Electrochemical cells are systems that convert chemical energy into electrical energy or use electrical energy to drive chemical reactions. They consist of two electrodes in contact with an electrolyte, where redox reactions enable electron transfer. Most electrochemical cells include two half-cells connected by an external wire for electron flow and a salt bridge for ion flow. The salt bridge contains an electrolyte solution and maintains charge neutrality by allowing ions—not electrons—to...
Interfacial Electrochemical Methods: Overview01:06

Interfacial Electrochemical Methods: Overview

Interfacial electrochemical methods focus on the phenomena occurring at the boundary between an electrode and a solution, as opposed to bulk methods that concentrate on the solution's overall properties. These interfacial methods are classified as either static or dynamic based on the presence of a nonzero current in the electrochemical cell and the consistency of analyte concentrations. Static methods, such as potentiometry, measure the cell's potential without any significant current passing...
Electrochemical Systems01:24

Electrochemical Systems

Electrochemical systems provide a fascinating insight into the dynamic interplay of charged species within various phases. One notable example is the interaction between a membrane permeable to K⁺ ions but not to Cl⁻ ions, separating an aqueous KCl solution from pure water. As K⁺ ions diffuse through the membrane, they generate net charges on each phase, leading to a potential difference between them.Similarly, when a piece of Zn is immersed in an aqueous ZnSO₄ solution, the Zn metal, composed...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reversible & Microbubble Concentration-Dependent Permeabilization of an <i>In Vitro</i> Human Endothelial Barrier to Small Molecules Using Ultrasound: Implications for Neurodegenerative Diseases Therapy.

Molecular pharmaceutics·2026
Same author

Targeted inner ear delivery of gadolinium using microbubble-assisted ultrasound in an ovine model.

International journal of pharmaceutics·2026
Same author

Microbubbles for Acoustically Mediated Drug Delivery to the Inner Ear.

Molecular pharmaceutics·2026
Same author

Decoding Cerebrospinal Fluid: Integrative Metabolomics Across Multiple Platforms.

Methods and protocols·2026
Same author

Therapeutic efficacy of in-vivo IL-12 plasmid delivery using microbubble-assisted ultrasound in a B16F10 mouse melanoma model: a proof of concept.

International journal of pharmaceutics·2025
Same author

Introduction to nanomedicines for crossing biological barriers.

Nanoscale·2025
Same journal

Role of Phenolic Nanocompounds in Inflammatory Disorders: Current View and Future Aspects.

Current pharmaceutical design·2026
Same journal

Overcoming Physiological Barriers in Brain Tumor Therapy: Advances in Nanomedicine, Ultramolecular Pharmaceuticals, and Targeted Drug Delivery.

Current pharmaceutical design·2026
Same journal

Breathing Life into Research: The Transformative Potential of Lung-on-a-Chip Technology.

Current pharmaceutical design·2026
Same journal

Cross-Tissue Transcriptome-Wide Association Study Prioritizes Candidate Genes and Compound-Associated Signatures for Osteoarthritis.

Current pharmaceutical design·2026
Same journal

Emerging Role of AI in Gastroenterology and Hepatology: Revolutionizing Medical Device-Assisted Diagnosis.

Current pharmaceutical design·2026
Same journal

Nanostructured Lipid Carriers in Drug Targeting: Characterization, Patents, and Recent Innovations.

Current pharmaceutical design·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

Electrochemotherapy: progress and prospects.

Jean-Michel Escoffre1, Marie-Pierre Rols

  • 1UMRS Inserm U "Imagerie et Cerveau" - Université François Rabelais de Tours, France. jean-michel.escoffre@univ-tours.fr

Current Pharmaceutical Design
|June 6, 2012
PubMed
Summary
This summary is machine-generated.

Electrochemotherapy (ECT) effectively treats recurrent tumors by using electric pulses to enhance chemotherapy drug delivery. This loco-regional therapy shows high response rates for unresectable nodules, offering a valuable palliative option.

Related Experiment Videos

Last Updated: May 21, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

Area of Science:

  • Oncology
  • Biomedical Engineering

Background:

  • Recurrent or unresectable cutaneous and subcutaneous tumors present significant therapeutic challenges.
  • Standard treatments like radiotherapy, chemotherapy, and surgery are often insufficient for these advanced-stage tumors.

Purpose of the Study:

  • To evaluate electrochemotherapy (ECT) as a palliative treatment for cutaneous and subcutaneous tumor nodules.
  • To highlight the mechanism and efficacy of ECT in enhancing anti-cancer drug delivery.

Main Methods:

  • ECT involves the local application of electric pulses to tumor cells to increase their permeability.
  • Antineoplastic drugs, such as cisplatin or bleomycin, are administered intravenously or intratumorally.
  • The electric pulses transiently increase cancer cell permeability to these drugs by up to a hundred-fold.

Main Results:

  • ECT demonstrates high overall objective response rates, approximately 80-90%, for unresectable recurrent tumor nodules.
  • The treatment offers satisfactory cosmetic results.
  • ECT is an efficient loco-regional therapy for palliative care.

Conclusions:

  • Electrochemotherapy is an effective loco-regional palliative treatment for unresectable recurrent cutaneous and subcutaneous tumors.
  • Future challenges include adapting ECT for deep-seated tumors and metastases.
  • Combining ECT with gene electrotransfer or electro-photodynamic therapy may offer promising strategies for cancer eradication.