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Updated: May 21, 2026
09:08
From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
[Plant-specific type III polyketide synthases superfamily: crystal structures and functions]
Heshu Lü1, Chunmei Liu, Ping Lu
1Key Laboratory of Urban Agriculture North) of Ministry of Agriculture China, Beijing University of Agriculture, Beijing 102206, China.
Summary
Plant type III polyketide synthases (PKS) are crucial for creating diverse plant compounds. This review details 7 plant-specific type III PKS structures and functions, aiding enzyme and metabolic engineering.
Area of Science:
- Biochemistry and Molecular Biology
- Plant Sciences
Context:
- Plant type III polyketide synthases (PKS) are key enzymes in secondary metabolite biosynthesis.
- Over 80 crystal structures of type III PKS are available, offering insights into enzyme mechanisms.
- Chalcone Synthase is a well-studied example of plant type III PKS.
Purpose:
- To review the crystal structures and functions of 7 plant-specific type III PKS.
- To elucidate the structure-function relationships in plant type III PKS.
- To provide a foundation for enzyme and metabolic engineering.
Summary:
- This review summarizes the crystal structures and functions of seven plant-specific type III polyketide synthases.
- It highlights the structural basis for starter molecule selectivity, polyketide chain length, and cyclization.
- Structure-based analysis and mutagenesis are crucial for understanding enzyme mechanisms.
Impact:
- Facilitates understanding of plant secondary metabolite diversity.
- Supports advancements in enzyme engineering and metabolic engineering for novel compound production.
- Provides a structural framework for investigating PKS family enzymes.
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