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Related Concept Videos

Simple Trusses01:21

Simple Trusses

A truss is a structural framework consisting of slender members connected at joints, designed to support external loads while minimizing material usage and weight. Simple trusses are a type of planar truss where all members lie within a single two-dimensional plane.
The most basic planar truss is a simple truss with three members arranged in a triangular formation. This triangular truss is inherently stable and rigid due to its geometry, making it an ideal starting point for creating more...
Introduction to Structures01:30

Introduction to Structures

A structure is defined as a system of interconnected members designed to support or transfer forces and successfully withstand the loads acting on them. The internal forces of a structure can be determined by decomposing the structure and analyzing the free-body diagrams of the individual members or of a combination of members. This helps in understanding the structural elements' behavior and ensuring that the structure is stable and can withstand the subjected loads.
There are three main...
Space Trusses01:25

Space Trusses

A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. The space truss is widely used in various construction projects due to its adaptability and capacity to withstand complex loads.
At the core of a space truss lies the fundamental unit known as the tetrahedron. This structure is composed of six members that form a three-dimensional shape...
Protein Translocation Machinery on the ER Membrane01:28

Protein Translocation Machinery on the ER Membrane

The translocon complex situated on the ER membrane is the main gateway for the protein secretory pathway. It facilitates the transport of nascent peptides into the ER lumen and their insertion into the ER membrane.
Sec61 protein conducting channel
In eukaryotes, the translocon complex comprises a core heterotrimeric translocator channel called the Sec61 complex. This channel includes three transmembrane proteins, Sec61α, Sec61β, and Sec61γ, and is the largest subunit of the translocon complex.
Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
Tight Junctions01:29

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...

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Related Experiment Video

Updated: May 21, 2026

Translating Ribosome Affinity Purification (TRAP) to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale
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Translating Ribosome Affinity Purification (TRAP) to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale

Published on: May 14, 2020

A trapper keeper for TRAPP, its structures and functions.

Sidney Yu1, Yongheng Liang

  • 1School of Biomedical Sciences and Epithelial Cell Biology Research Center, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR, People's Republic of China, sidney.yu@cuhk.edu.hk.

Cellular and Molecular Life Sciences : CMLS
|June 7, 2012
PubMed
Summary

The transport protein particle (TRAPP) complex is crucial for vesicle transport in cells. Recent research reveals new insights into the structures and diverse functions of TRAPP complexes.

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TRAP-rc, Translating Ribosome Affinity Purification from Rare Cell Populations of Drosophila Embryos
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Related Experiment Videos

Last Updated: May 21, 2026

Translating Ribosome Affinity Purification (TRAP) to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale
09:41

Translating Ribosome Affinity Purification (TRAP) to Investigate Arabidopsis thaliana Root Development at a Cell Type-Specific Scale

Published on: May 14, 2020

Quantifying Corticolous Arthropods Using Sticky Traps
05:28

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TRAP-rc, Translating Ribosome Affinity Purification from Rare Cell Populations of Drosophila Embryos
10:26

TRAP-rc, Translating Ribosome Affinity Purification from Rare Cell Populations of Drosophila Embryos

Published on: September 10, 2015

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Protein Trafficking

Background:

  • Membrane and secreted proteins are transported via vesicles from the endoplasmic reticulum through the Golgi to the plasma membrane.
  • Vesicle transport involves sequential steps: budding, movement, tethering, docking, and fusion.
  • The transport protein particle (TRAPP) complex was first identified as a tethering factor for COPII vesicles originating from the endoplasmic reticulum.

Purpose of the Study:

  • To provide a comprehensive review of recent findings in TRAPP biology.
  • To highlight new insights into the structures and functions of TRAPP complexes.
  • To explore the potential broader roles of TRAPP beyond its initial identification.

Main Methods:

  • Literature review of recent research on TRAPP complexes.
  • Analysis of structural and functional data from various studies.
  • Synthesis of information on the different forms of TRAPP.

Main Results:

  • Three distinct forms of the TRAPP complex have been identified.
  • Recent research has significantly advanced our understanding of TRAPP structures.
  • New functional roles for TRAPP complexes are emerging in cell biology.

Conclusions:

  • TRAPP complexes play a vital role in intracellular protein transport.
  • The diverse functions of TRAPP complexes extend beyond ER-derived vesicle tethering.
  • Continued research is essential for fully elucidating TRAPP's contributions to cellular processes.