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Updated: May 21, 2026
06:33
Massive Pontine Hemorrhage by Dual Injection of Autologous Blood
Published on: May 29, 2021
Massive Bleeding and Massive Transfusion.
Andreas Meißner1, Peter Schlenke
1Klinik für Anästhesie, Intensiv-und Notfallmedizin, Schmerztherapie und Palliativmedizin, Klinikum Stadt Soest, Germany.
Summary
Massive bleeding in trauma patients requires rapid, interdisciplinary care. Higher ratios of plasma to packed red blood cells (RBCs) and platelet transfusions may improve survival in trauma-induced coagulopathy.
Area of Science:
- Emergency Medicine
- Trauma Surgery
- Hematology
Background:
- Massive bleeding in trauma is a life-threatening emergency requiring prompt intervention.
- Trauma-induced coagulopathy is exacerbated by clotting factor consumption and dilution.
- Current management strategies lack universally accepted algorithms for transfusion and coagulation support.
Purpose of the Study:
- To review current literature on managing massive hemorrhage in trauma patients.
- To discuss optimal fluid resuscitation, blood transfusion, and coagulation strategies.
- To provide insights for optimizing blood and coagulation management in emergency medical aid.
Main Methods:
- Literature review of fluid resuscitation, blood transfusion, and hemostatic agents.
- Analysis of strategies for trauma-induced massive hemorrhage.
- Focus on optimizing patient outcomes within a limited time frame.
Main Results:
- Evidence suggests a higher plasma to packed red blood cell (RBC) ratio (e.g., 1:1) with platelet transfusion may improve survival.
- Military strategies, like whole blood transfusion, require careful evaluation for civilian application.
- Some hemostatic agents show benefit, while others have demonstrated inefficacy or severe side effects.
Conclusions:
- An interdisciplinary approach is crucial for managing massive trauma bleeding.
- Optimizing transfusion ratios and coagulation support is key to improving patient survival.
- Further research is needed to refine evidence-based algorithms for trauma-induced coagulopathy.
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