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Typhoid hepatitis.

S N Khosla1

  • 1Department of Medicine, Medical College and Hospital, (Haryana), India.

Postgraduate Medical Journal
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Typhoid hepatitis, a rare liver complication of typhoid fever, presents with jaundice and hepatomegaly. Early diagnosis and treatment are crucial for a good prognosis in these uncommon cases.

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Liver involvement in typhoid fever is considered uncommon.
  • Typhoid hepatitis is increasingly recognized as a distinct clinical entity.
  • This study investigates the characteristics and outcomes of typhoid hepatitis.

Purpose of the Study:

  • To determine the incidence of typhoid hepatitis in patients with typhoid fever.
  • To describe the clinical presentation, biochemical findings, and histopathological features of typhoid hepatitis.
  • To emphasize the importance of differentiating typhoid hepatitis from other tropical liver diseases.

Main Methods:

  • A retrospective analysis of 210 typhoid fever cases over 4 years.
  • Inclusion criteria: presence of typhoid fever with liver involvement.

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  • Diagnostic methods included clinical examination, biochemical tests, and liver biopsy in select cases.

    • Main Results:

    • Ten cases (4.8%) of typhoid hepatitis were identified.
    • All patients presented with jaundice, anemia, hepatomegaly, and abnormal liver function tests.
    • Liver biopsy revealed abnormalities in 5 out of 8 cases.
    • Two patients (20%) with typhoid hepatitis unfortunately died.

    Conclusions:

    • Typhoid hepatitis, though uncommon, is a significant complication of typhoid fever.
    • Prompt recognition and differentiation from other tropical hepatitis are essential.
    • Timely administration of specific antimicrobial therapy improves the prognosis for typhoid hepatitis.