Related Experiment Videos
Histiocytic cytophagic panniculitis
D A Hilton1, B P O'Malley, S T Durrant
1Department of Histopathology, Leicester Royal Infirmary, Infirmary Square, UK.
Postgraduate Medical Journal
|November 1, 1990
Summary
A rare condition, histiocytic cytophagic panniculitis, presented with fever, jaundice, and pancytopenia. Despite chemotherapy, the patient
Area of Science:
- Hematology
- Dermatopathology
- Oncology
Background:
- Histiocytic cytophagic panniculitis is a rare, potentially fatal disorder.
- It is characterized by systemic inflammation and hemophagocytosis.
Observation:
- A 33-year-old male presented with fever, jaundice, pancytopenia, and hepatomegaly.
- Skin biopsy revealed lobular panniculitis with cytophagic histiocytes.
- Erythrophagocytosis was confirmed in liver and bone marrow.
Findings:
- The patient's condition worsened despite cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisolone (CHOP) chemotherapy.
- The clinical presentation and biopsy findings were consistent with histiocytic cytophagic panniculitis.
Implications:
- This case highlights the aggressive nature of histiocytic cytophagic panniculitis.
- Early recognition and further research into effective treatments are crucial for improving patient outcomes.