Related Experiment Video
Updated: May 21, 2026

Long-Term Continuous Measurement of Renal Blood Flow in Conscious Rats
Published on: February 8, 2022
[Metformin-associated lactic acidosis can be treated with continuous renal replacement therapy]
Helene Korvenius Jørgensen1, Jane Stab Nielsen, Torben Gilsaa
1Anæstesiologisk Afdeling, Kolding Sygehus, Skovvangen 2-8, 6000 Kolding, Denmark. helene_j@yahoo.com
Abstract:
Metformin is widely used to treat diabetes. In rare cases, metformin may cause lactic acidosis, especially when administered during periods of dehydration. We present two cases of metformin-associated lactic acidosis (MALA). Both patients presented with metabolic acidosis, hypotension, renal failure and gastrointestinal symptoms. The use of continuous renal replacement therapy (CRRT) had a significant effect. Lactate and metformin can be removed effectively by haemofiltration. CRRT is widely available and a well-known treatment at intensive care units. MALA shows a mortality rate of about 30%.
Related Concept Videos
Continuous Renal Replacement Therapy
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Chronic Kidney Disease III: Interprofessional Care
Oral Hypoglycemic Agents: Biguanides and Glitazones
Diabetic Ketoacidosis l: Introduction
Acute Kidney Injury V: Interprofessional Care
