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Updated: May 21, 2026

Rectal Organoid Morphology Analysis (ROMA): A Diagnostic Assay in Cystic Fibrosis
Published on: June 10, 2022
[Cronkhite-Canada syndrome is a rare polyposis syndrome]
Anja Poulsen1, Malene Fey Nielsen
1Medicinsk Afdeling, Slagelse Sygehus, Denmark. anjapoulsen@live.dk
Abstract:
Cronkhite-Canada syndrome (CCS) is rare and associated with diarrhoea, gastrointestinal polyps, malnutrition, weight loss, alopecia, skin- and nail changes. The patient was hospitalized with dehydration, diarrhoea and weight loss. Objectively emaciated, skin changes, poor nail status and alopecia. Biochemistry compatible with malnutrition. Gastroscopy showed polyps. Treatment of symptomatic replacement therapy and prednisolone resulted in remission. It is a diagnosis with a 55% 5-year mortality. Early treatment leads to better prognosis.
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