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Updated: May 21, 2026
08:12
Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
Published on: December 16, 2022
Functional monolithic materials for boronate-affinity chromatography via Schrock catalyst-triggered ring-opening
Rajendar Bandari1, Michael R Buchmeiser
1Institute of Polymer Chemistry, University of Stuttgart, Stuttgart, Germany. ipobuch@ipoc.uni-stuttgart.de
Macromolecular Rapid Communications
|June 8, 2012
Summary
New monolithic polymeric materials were created using ring-opening metathesis copolymerization. These functionalized materials are effective for affinity chromatography, enabling the separation of cis-diol biomolecules.
Area of Science:
- Polymer Chemistry
- Materials Science
- Chromatography
Background:
- Monolithic polymeric materials offer unique properties for separation sciences.
- Ring-opening metathesis polymerization (ROMP) is a versatile technique for polymer synthesis.
Purpose of the Study:
- To synthesize functionalized monolithic polymeric materials via ROMP.
- To evaluate the application of these materials in affinity chromatography.
Main Methods:
- Ring-opening metathesis copolymerization of norbornene derivatives using a Schrock catalyst.
- Functionalization via living metal alkylidene termination or post-synthesis grafting.
- Preparation of boronate-grafted monolithic columns.
Main Results:
- Successful synthesis of monolithic polymeric materials with controlled functionalization.
- Demonstration of affinity chromatographic separation of cis-diol biomolecules using boronate-grafted columns.
- Effective separation achieved with 100 × 3 mm i.d. columns.
Conclusions:
- Functionalized monolithic polymers are viable materials for affinity chromatography.
- The developed method allows for tailored materials for specific biomolecule separations.
- Boronate-grafted monoliths show promise for cis-diol separation applications.
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