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Updated: May 21, 2026
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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
Published on: May 10, 2017
SET oncogene is upregulated in pediatric acute lymphoblastic leukemia
Sema Sirma Ekmekci1, Cumhur G Ekmekci, Ayten Kandilci
1Istanbul University, Institute of Experimental Medicine, Department of Genetics, Istanbul, Turkey.
Tumori
|June 9, 2012
Summary
The SET gene is significantly overexpressed in pediatric acute lymphoblastic leukemia (ALL). This increased SET expression may play a role in the development of leukemia.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- The SET gene encodes a multifunctional phosphoprotein.
- SET is known to be upregulated in various cancer types, including BCR-ABL1-positive leukemia and solid tumors.
Purpose of the Study:
- To investigate the expression level of the SET gene in pediatric acute lymphoblastic leukemia (ALL) patients.
- To determine the association between SET expression and clinical features or survival outcomes in pediatric ALL.
Main Methods:
- Quantitative real-time reverse-transcription polymerase chain reaction (RT-PCR) was used to measure SET gene expression.
- The study included 59 pediatric patients diagnosed with BCR-ABL-negative ALL.
Main Results:
- SET expression was significantly upregulated in 96.5% of B-ALL and 93% of T-ALL pediatric patients.
- The observed SET upregulation was not correlated with any clinical features, overall survival, or relapse-free survival.
Conclusions:
- SET is significantly overexpressed in pediatric acute lymphoblastic leukemia.
- Elevated SET levels may contribute to the leukemic process in ALL.
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