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Updated: May 21, 2026
An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
[Full sequence analysis for a null allele of MICA gene (MICA*063N)]
Ying-feng Huang1, Yin Tan, Shao-yu Yang
1Department of Surgery, Guangzhou First Municipal People's Hospital Affiliated to Guangzhou Medical College, Guangzhou, Guangdong 510180, P.R.China. huangyingfeng@yahoo.com.cn
Objective:
To analyze the full nucleotide sequence of a null allele of major histocompatibility complex class I chain-related gene (MICA).
Methods:
A sequence-based typing method was used to determine the nucleotide sequence of the MICA gene. Potential alleles were identified with a computer program.
Results:
The identified allele has possessed a sequence similar to that of MICA*027 except for a C→T substitution at position 184 in codon 62 (CAG→TAG) of exon 2. As a stop codon, this may result in a truncated protein.
Conclusion:
A null allele of MICA gene has been identified. The sequence has been submitted to the Genbank nucleotide sequence database (submission No. HWS10011131), which was officially named as MICA*063N by the WHO Nomenclature Committee in October 2010.
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