Related Experiment Videos
A vase-like shape characterizes the epidermal-mononuclear cell collections seen in spongiotic dermatitis
1Department of Pathology, University of California, San Francisco 94143-0506.
Abstract:
Collections of mononuclear cells are seen within the epidermis in both mycosis fungoides and spongiotic dermatitis. Criteria have been proposed to differentiate between such Pautrier microabscesses or collections, and thier spongiotic mimics. We noted that the collections often assume a vase-like shape when spongiosis is present, with the lips of the vase situated at the interface between granular and cornified layers. Vase-shaped collections were present in five of 49 consecutive biopsy specimens of spongiotic dermatitis, but in none of 50 specimens of mycosis fungoides. These collections can, however, be seen in mycosis fungoides when pronounced spongiosis is present and should be considered as a marker of the process, spongiosis, rather than being diagnostic of spongiotic dermatitis.
Insights
Vase-shaped mononuclear cell collections in the epidermis can mimic Pautrier microabscesses. These collections are markers of spongiosis, not definitively diagnostic of spongiotic dermatitis in mycosis fungoides.
Area of Science:
- Dermatopathology
- Histopathology
Background:
- Mononuclear cell collections in the epidermis occur in both mycosis fungoides and spongiotic dermatitis.
- Distinguishing between Pautrier microabscesses and spongiotic mimics is clinically important.
Purpose of the Study:
- To evaluate the diagnostic utility of vase-shaped epidermal collections in differentiating spongiotic dermatitis from mycosis fungoides.
- To identify specific histological features that aid in differential diagnosis.
Main Methods:
- Retrospective analysis of 49 biopsy specimens of spongiotic dermatitis and 50 of mycosis fungoides.
- Histological examination focusing on epidermal mononuclear cell collections and their morphology.
Main Results:
- Vase-shaped collections were observed in 5 of 49 (10.2%) spongiotic dermatitis cases.
- No vase-shaped collections were found in 50 mycosis fungoides specimens.
- Vase-shaped collections can be present in mycosis fungoides with significant spongiosis.
Conclusions:
- Vase-shaped epidermal collections are a potential marker of spongiosis.
- These collections are not exclusive to spongiotic dermatitis and can be seen in mycosis fungoides.
- Their presence should prompt consideration of spongiosis rather than being solely diagnostic of spongiotic dermatitis.