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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Microdosimetric analysis of 211At in thyroid models for man, rat and mouse
Anders Josefsson1, Eva Forssell-Aronsson
1Department of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Cancer Center, Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, 413 45, Sweden. anders.josefsson@radfys.gu.se.
EJNMMI Research
|June 12, 2012
Summary
Developing accurate thyroid models for alpha particle emitter 211At is crucial for radiation protection. These models help assess dosimetry in patients and personnel, ensuring safety during targeted cancer therapy.
Area of Science:
- Radiological Physics
- Nuclear Medicine
- Medical Physics
Background:
- Astatine-211 (211At) alpha emitter shows promise for metastatic tumor therapy, accumulating in the thyroid like iodine.
- Accurate dosimetric models for 211At in the thyroid are essential for radiation protection assessments.
- Preclinical studies in mice and rats necessitate species-specific thyroid models for dosimetric comparisons.
Purpose of the Study:
- To develop and compare microdosimetric properties of thyroid models for mouse, rat, and human.
- To establish dosimetric models for 211At in the thyroid for radiation protection.
- To facilitate the translation of dosimetric parameters between preclinical and clinical applications.
Main Methods:
- Constructed a thyroid follicle model including follicle cells, nuclei, and lumen.
- Defined species-specific models for mouse, rat, and man.
- Utilized Monte Carlo simulations with MCNPX 2.6.0 for radiation transport analysis.
Main Results:
- Mean specific energies per decay (〈z〉) to the follicle cell nucleus were 2.0, 1.1, and 0.17 mGy for mouse, rat, and man, respectively.
- Single-hit mean specific energies per decay (〈z1〉) were 1.3, 0.61, and 0.37 Gy.
- Alpha particle self-absorption within the follicle lumen varied significantly by species (0.5% mouse, 7% rat, 45% man).
Conclusions:
- Thyroid follicle size, alpha particle range, and 211At location significantly impact dosimetric parameters.
- Species-specific thyroid models are necessary for accurate dosimetric assessments.
- Validated models are crucial for translating preclinical findings to clinical settings and ensuring radiation safety.
