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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Fungal Group Zygomycota01:29

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
Fungal Phylum Basidiomycota01:26

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus
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Published on: June 6, 2025

Chromoblastomycosis.

Edoardo Torres-Guerrero1, Rafael Isa-Isa, Mariel Isa

  • 1Mycology Section, Department of Dermatology, Dr. Manuel Gea Gonzalez General Hospital, Calzada de Tlalpan 4800, Colonia Sección XVI, Mexico, DF Mexico.

Clinics in Dermatology
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

Chromoblastomycosis is a chronic fungal infection causing skin lesions, often on the legs. Treatment can be challenging, involving antifungals like itraconazole or terbinafine, sometimes with surgery.

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Area of Science:

  • Mycology
  • Dermatology
  • Infectious Diseases

Background:

  • Chromoblastomycosis is a chronic subcutaneous fungal infection.
  • It presents as verrucous nodular lesions, typically on the legs.
  • Common causative agents include Fonsecaea, Phialophora, and Cladophialophora species.

Purpose of the Study:

  • To summarize the key characteristics of chromoblastomycosis.
  • To highlight diagnostic findings.
  • To outline current therapeutic strategies.

Main Methods:

  • Review of literature on chromoblastomycosis.
  • Analysis of diagnostic features.
  • Compilation of treatment options.

Main Results:

  • Characteristic diagnostic findings include fumagoid cells or Medlar bodies in direct examination or biopsy.
  • The infection can be refractory to standard medical treatments.
  • Effective therapeutic options involve oral antifungals such as itraconazole, terbinafine, or 5-fluocytosine.

Conclusions:

  • Chromoblastomycosis requires specific diagnostic identification of Medlar bodies.
  • Treatment often necessitates a combination of systemic antifungals and surgical or physical interventions.
  • Management can be complex due to treatment refractoriness.