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Updated: May 21, 2026

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

Necrotizing enterocolitis.

Kathleen M Dominguez1, R Lawrence Moss

  • 1Department of Surgery, Nationwide Children's Hospital, The Ohio State University College of Medicine, 700 Children's Drive, Columbus, OH 43205, USA.

Clinics in Perinatology
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

Necrotizing enterocolitis (NEC) is a severe gastrointestinal condition in premature infants, often requiring surgery. Outcomes for surgical NEC patients, regardless of approach, are associated with significant long-term complications.

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Last Updated: May 21, 2026

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
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Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Area of Science:

  • Neonatal Medicine
  • Pediatric Surgery
  • Gastroenterology

Background:

  • Necrotizing enterocolitis (NEC) is a leading cause of mortality in neonatal intensive care units.
  • It is the most frequent acquired gastrointestinal disorder among premature neonates.
  • NEC poses significant risks for morbidity and mortality in this vulnerable population.

Purpose of the Study:

  • To review the current understanding of necrotizing enterocolitis in premature neonates.
  • To discuss the necessity and options for surgical intervention in progressive NEC cases.
  • To highlight the long-term sequelae faced by survivors of surgical NEC.

Main Methods:

  • Review of existing literature on necrotizing enterocolitis.
  • Analysis of surgical treatment modalities for NEC.
  • Examination of outcomes and complications in NEC survivors.

Main Results:

  • Surgical intervention is indicated for NEC cases unresponsive to medical management.
  • Surgical approaches, including peritoneal drainage and laparotomy, show comparable outcomes.
  • Survivors of NEC, especially surgical NEC, experience substantial long-term health issues.

Conclusions:

  • NEC remains a critical neonatal surgical emergency with high stakes.
  • The choice between peritoneal drainage and laparotomy does not significantly alter patient outcomes.
  • Effective management strategies are needed to mitigate the severe sequelae in NEC survivors.