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Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
Prodrugs01:30

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
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Published on: December 1, 2020

Open PHACTS: semantic interoperability for drug discovery.

Antony J Williams1, Lee Harland, Paul Groth

  • 1Royal Society of Chemistry, ChemSpider, US Office, Wake Forest, NC 27587, USA. tony27587@gmail.com

Drug Discovery Today
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

The Open PHACTS project aims to create an open pharmacological space using semantic web technologies to advance drug discovery research. It addresses technical and social challenges to foster innovation in academia and industry.

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Area of Science:

  • Pharmacology
  • Bioinformatics
  • Semantic Web Technologies

Background:

  • The drug discovery process faces challenges in data integration and accessibility.
  • Academia and industry require improved tools for collaborative research and innovation.

Purpose of the Study:

  • To establish and maintain an open pharmacological space.
  • To leverage semantic web standards for practical drug discovery applications.
  • To address technical and social challenges in drug discovery research.

Main Methods:

  • Utilizing state-of-the-art semantic web standards and technologies.
  • Developing practical and robust applications for specific drug discovery questions.
  • Fostering a public-private partnership model.

Main Results:

  • The Open PHACTS project is designed to facilitate improvements in drug discovery.
  • It supports both open innovation and non-public in-house research.
  • The project outlines strategies for overcoming identified challenges.

Conclusions:

  • The Open PHACTS initiative provides a framework for enhancing drug discovery through open collaboration and advanced technologies.
  • Addressing both technical and social aspects is crucial for the success of such initiatives.