Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selenium-Containing 1,4-Naphthoquinone Derivatives Trigger Reactive Oxygen Species and Apoptosis in Triple-Negative Breast Cancer Cells.

Drug development research·2026
Same author

Handheld hyperspectral imaging dataset of annual sowthistle and little mallow under abiotic stress for machine learning.

Data in brief·2026
Same author

Microbial dysbiosis in metabolic disorders: linking epigenomic regulation and pathological mechanisms.

Drug discovery today·2026
Same author

Laryngeal leishmaniasis presenting with hoarseness in a child from the highland of Nepal: A rare diagnostic challenge.

IDCases·2026
Same author

CerS2 Is a Druggable Target in Triple-Negative Breast Cancer.

Molecular cancer therapeutics·2026
Same author

Human-Centric Modeling in Metastatic Breast Cancer: Organoids, Organ-on-Chip Systems, and New Approach Methodologies in the Post-FDA Modernization Act 2.0 Era.

Cancers·2026
Same journal

Hyaluronic Acid Hydrogel Inhibits Autophagy Through the miR-181a-5p/ATG5 Molecular Axis to Promote the Adipogenic Differentiation of Adipose-Derived Stem Cells.

Stem cells international·2026
Same journal

RETRACTION: Naringin Stimulates Osteogenic Differentiation of Rat Bone Marrow Stromal Cells via Activation of the Notch Signaling Pathway.

Stem cells international·2026
Same journal

Efficient Derivation and Transcriptional Characterization of Mouse Extra-Embryonic Endoderm Stem Cell Lines Generated by Somatic Cell Nuclear Transfer.

Stem cells international·2026
Same journal

Neuroprotection After Intracerebral Hemorrhage: Apoptosis, Neurogenesis, and Prospects of Stem Cell Therapy.

Stem cells international·2026
Same journal

Amentoflavone Suppresses Stemness of Retinoblastoma Cell via Targeting Smoothened (SMO) Protein.

Stem cells international·2026
Same journal

Sodium Nitrate Combined With Dental Pulp Stem Cells Alleviates Atherosclerosis Through Inhibiting Oxidative Stress.

Stem cells international·2026
See all related articles

Related Experiment Video

Updated: May 21, 2026

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells
14:04

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Published on: August 1, 2020

Engaging stem cells for customized tendon regeneration.

Hatim Thaker1, Arun K Sharma

  • 1Division of Pediatric Urology, Children's Memorial Hospital of Chicago, Chicago, IL, USA.

Stem Cells International
|June 12, 2012
PubMed
Summary
This summary is machine-generated.

Developing consistent tendon repair strategies is crucial. This study explores using bone-marrow-derived stem cells and novel biomaterial scaffolds for improved tendon regeneration and patient outcomes.

More Related Videos

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension
04:48

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

Published on: March 1, 2024

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair
08:32

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Related Experiment Videos

Last Updated: May 21, 2026

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells
14:04

Applying a Three-dimensional Uniaxial Mechanical Stimulation Bioreactor System to Induce Tenogenic Differentiation of Tendon-Derived Stem Cells

Published on: August 1, 2020

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension
04:48

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension

Published on: March 1, 2024

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair
08:32

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Tendon injuries lack a standardized therapeutic approach, leading to varied patient outcomes.
  • Current surgical interventions for tendon repair show promise but lack conclusive data on optimal graft constructs.
  • Understanding tendon healing mechanisms and architecture has advanced tissue regeneration research.

Purpose of the Study:

  • To evaluate the potential of bone-marrow-derived stem cells and advanced biomaterials for tendon regeneration.
  • To explore the use of mesenchymal stem cells (MSCs) and hematopoietic progenitor cells with poly(1,8-octanediol co-citrate) (POC) scaffolds.
  • To investigate the development of a fibroelastic network for enhanced tendon graft constructs.

Main Methods:

  • Assessment of mesenchymal stem cells (MSCs) plasticity for tendon repair.
  • Evaluation of poly(1,8-octanediol co-citrate) (POC) scaffolds' elasticity and suitability for cell growth.
  • Discussion of cytokine and growth factor integration in scaffold-guided cell proliferation.

Main Results:

  • Bone-marrow-derived stem cells, including MSCs and hematopoietic progenitor cells, show promise in tissue regeneration.
  • POC scaffolds provide a suitable environment for cell growth, potentially forming a fibroelastic network.
  • Cytokines and growth factors can guide the development of regenerated tendon tissue.

Conclusions:

  • Combining POC scaffolds with MSCs and hematopoietic progenitor cells offers a pathway to consistent tendon graft constructs.
  • This approach may lead to improved functionality and better patient outcomes in tendon injury repair.
  • Further research into guided tissue regeneration holds significant potential for orthopedic interventions.