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Related Concept Videos

Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...

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Related Experiment Video

Updated: May 21, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Peripheral ossifying fibroma.

Parveen Dahiya1, Reet Kamal, Gaurav Saini

  • 1Department of Periodontics, Himachal Institute of Dental Sciences and Research, Paonta Sahib, Dist: Sirmour.

Journal of Natural Science, Biology, and Medicine
|June 13, 2012
PubMed
Summary
This summary is machine-generated.

A peripheral ossifying fibroma (POF) case in a teen

Keywords:
Gingivamandibularperipheral ossifying fibroma

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Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Area of Science:

  • Oral pathology
  • Odontogenic tumors

Background:

  • Peripheral ossifying fibroma (POF) is a benign reactive hyperplasia of the gingiva.
  • It typically occurs in the anterior maxilla but can present in the mandible.
  • Accurate diagnosis is crucial for appropriate management.

Observation:

  • A 17-year-old male presented with an asymptomatic, firm, pink lesion.
  • The lesion was located on the lingual alveolar mucosa of the mandible, between teeth 43 and 44.
  • Radiographic examination showed no significant abnormalities.

Findings:

  • Excisional biopsy was performed for definitive diagnosis and treatment.
  • Histopathological examination confirmed the presence of a peripheral ossifying fibroma.
  • Microscopic features included cellular connective tissue with calcifications and ossification.

Implications:

  • This case highlights the occurrence of POF in the mandibular gingiva of adolescents.
  • Surgical excision is the standard treatment for peripheral ossifying fibroma.
  • Early diagnosis and complete removal prevent recurrence and potential complications.