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A Patient-Derived Xenograft Model for Venous Malformation

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Published on: June 15, 2020

A virulent vasculopathy.

A Molloy¹, D Forde, C De Gascun

¹Department of Neurology, Cork University Hospital, Cork, Ireland. annamolusa@gmail.com

BMJ Case Reports

|June 16, 2012

Summary

This summary is machine-generated.

Varicella zoster virus (VZV) can cause arteriopathy in immunocompetent adults. Prompt antiviral treatment led to the resolution of neurological symptoms and imaging findings in a VZV-negative patient.

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Area of Science:

Neurology
Infectious Diseases
Vascular Medicine

Background:

Arteriopathy is a rare complication of primary varicella zoster virus (VZV) infection.
This complication is particularly uncommon in immunocompetent adults.

Observation:

A 39-year-old VZV-negative woman presented with transient expressive aphasia and right upper limb paresthesia.
Symptoms followed a prodrome of malaise, arthralgia, and a generalized rash.
Neurological symptoms were linked to focal cerebritis and vasculopathy.

Findings:

Varicella zoster virus (VZV) infection was confirmed via cerebrospinal fluid PCR analysis.
Imaging demonstrated focal cerebritis and vasculopathy consistent with VZV infection.
The patient had no detected immunocompromise but had a known infectious contact.

Implications:

Early antiviral therapy can lead to the resolution of VZV-induced vasculopathy and neurological deficits.
Highlights the importance of considering VZV in adult-onset neurological events, even in VZV-negative individuals.
Underscores the potential for VZV to cause cerebrovascular complications in immunocompetent hosts.