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Related Experiment Video

Updated: May 21, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Does high antibiotic consumption still reflect bad practices?

T Levent¹, F Delfosse, F Lambiotte

¹Équipe opérationnelle en hygiène, Référent antibiotique, Centre hospitalier de Sambre-Avesnois, boulevard Pasteur, 59600 Maubeuge, France. t levent@ch-sa.com

Medecine Et Maladies Infectieuses

|June 19, 2012

Summary

Antibiotic prescription quality in intensive care units (ICUs) was assessed, finding most prescriptions adequate despite high consumption. Patient factors and bacterial resistance influence antibiotic use, suggesting de-escalation and optimized dosing can improve rates.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

Published on: July 21, 2023

Area of Science:

Infectious Diseases
Critical Care Medicine
Pharmacology

Background:

Intensive care units (ICUs) exhibit high antibiotic consumption rates.
Assessing antibiotic prescription quality is crucial for optimizing patient outcomes and combating antimicrobial resistance.

Purpose of the Study:

To evaluate the quality of antibiotic prescriptions in an ICU setting.
To identify factors contributing to high antibiotic consumption.

Main Methods:

A prospective study analyzed 50 prescriptions for specific antibiotics (ciprofloxacin, levofloxacin, teicoplanin, vancomycin, imipenem) over 5 months.
Treatment adequacy was assessed on day 5 based on relevant indication, correct dosage, and antibiogram compatibility.

Main Results:

Eighty-four percent (42/50) of antibiotic treatments were deemed adequate at day 5.
Glycopeptides and fluoroquinolones comprised two-thirds of prescriptions.
The most common error was the absence of de-escalation; patients were often severe, with high BMI and invasive device use, and 47% mortality.

Conclusions:

While most prescriptions were adequate, patient profiles (severity, obesity) and bacterial resistance patterns contribute to high antibiotic consumption.
Strategies like de-escalation, increased use of aminoglycosides, and shorter fluoroquinolone courses may improve antibiotic stewardship.
Antibiotic use in ICUs requires careful consideration of bacterial ecology and individual patient needs.